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KMID : 0356619950100010026
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Journal of Korean Society of Endocrinology
1995 Volume.10 No. 1 p.26 ~ p.34
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Immunohistochemical Study of c-Myc, c-Fos and c-Jun Oncoprotein Expression in the Human Pheochromocytoma
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조재화
이은직/남문석/김경래/남수연/송영득/임승길/이현철/허갑범
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Abstract
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A large number of studies for genesis involved in oncogenesis have bene done during last decade. Over 20 oncogenes have been isolated and characterized, and the oncogene expressions in human tumors have been examined. The proto-oncogenes of
c-myc,
c-fos
and c-jun, which modulate the transcription factors, have overexpressed in a variety of human cancers.
Immunohistochemical method was used in this study to examine c-Myc, c-Fos and c-Jun oncoprotein expression in 31 patients with human pheochromocytoma 28(90.0%) were benign and 3(10.0%) malignant. C-Myc oncoprotein immunoreactivity was found in 24
cases(77.4%), c-Fus in 29(93.5%), and c-Jun in 25(80.6%). Twenty-one(67.7%) showed positive immunoreactivity for all these oncoproteins, six(19.4%) for 2 oncoprotein, 3 for one oncoprotein. Only 1 case showed negative immunoreactivity for all 3
oncoproteins. The oncoprotein immunoreactivity did not correlate with the amount of 24 hour urinary catecholamine excretion. Although the number of malignant pheochromocytomas was not so many, most of them showed that the immunoreactivity for
oncoprotein was more than 30 percent of tumor cells.
The expression of c-Myc, c-Fos and c-Jun oncoprotein were frequently found in human pheochromocytoma. These results suggest that the oncoprotein expression may play an important role in tumorogenesis and proliferation of human pheochromocytoma(J
Kor Soc
Endocrinol 10:26-34, 1995).
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KEYWORD
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